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Table 3 Association between vitamin D status in the second trimester and the risk of GDM

From: Maternal vitamin D status and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study

25(OH)D status

Risk of GDM

 

Crude RR (95%CI)

P-value

Adjusted RR a (95%CI)

P-value

All participants

    

Sufficiency (≥ 30 ng/mL)

1.00

 

1.00

 

Insufficiency (20–30 ng/mL)

1.98 (1.37, 2.87)

< 0.001

1.85 (1.28, 2.67)

0.001

Deficiency (< 20 ng/mL)

1.44 (0.91, 2.27)

0.119

1.37 (0.88, 2.14)

0.168

Overweight participants

    

Sufficiency (≥ 30 ng/mL)

1.00

 

1.00

 

Insufficiency (20–30 ng/mL)

3.23 (1.55, 6.70)

0.002

3.55 (1.75, 7.20)

0.001

Deficiency (< 20 ng/mL)

2.36 (0.95, 5.86)

0.065

2.38 (1.03, 5.53)

0.043

Non-overweight participants

    

Sufficiency (≥ 30 ng/mL)

1.00

 

1.00

 

Insufficiency (20–30 ng/mL)

1.60 (1.01, 2.53)

0.043

1.47 (0.92, 2.36)

0.106

Deficiency (< 20 ng/mL)

1.26 (0.74, 2.15)

0.392

1.21 (0.72, 2.04)

0.472

Participants ≥ 35 years

    

Sufficiency (≥ 30 ng/mL)

1.00

 

1.00

 

Insufficiency (20–30 ng/mL)

3.06 (1.41, 6.65)

0.005

2.88 (1.25, 6.61)

0.013

Deficiency (< 20 ng/mL)

1.70 (0.56, 5.13)

0.346

1.67 (0.53, 5.26)

0.378

Participants < 35 years

    

Sufficiency (≥ 30 ng/mL)

1.00

 

1.00

 

Insufficiency (20–30 ng/mL)

1.72 (1.15, 2.65)

0.012

1.67 (1.09, 2.56)

0.018

Deficiency (< 20 ng/mL)

1.39 (0.84, 2.30)

0.194

1.34 (0.82, 2.18)

0.246

  1. GDM gestational diabetes mellitus, RR relative ratio
  2. aAdjusted for maternal age, prepregnancy BMI, education level, employment status, parity, mode of conception and family history of diabetes